• Acta Obstet Gynecol Scand · Jan 2007

    Randomized Controlled Trial Comparative Study

    Epidural ondansetron is more effective to prevent postoperative pruritus and nausea than intravenous ondansetron in elective cesarean delivery.

    • Dong Woo Han, Soon Won Hong, Ja-Young Kwon, Jae Woo Lee, and Ki Jun Kim.
    • Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Korea.
    • Acta Obstet Gynecol Scand. 2007 Jan 1;86(6):683-7.

    BackgroundPostoperative pruritus, nausea, and vomiting are common side effects of intrathecal or epidural opioids. Intravenous ondansetron has been used for postoperative emesis. However, there are no reports regarding epidural ondansetron. Two studies were conducted to evaluate the prophylactic effects of epidural ondansetron for opioid-induced pruritus, nausea, and vomiting.MethodsNeurotoxic signs were checked after epidural injection of ondansetron in rats. A clinical study was conducted to compare the prophylactic effects of epidural ondansetron with intravenous ondansetron for opioid-induced pruritus, nausea, and vomiting in cesarean delivery.ResultsNo neurotoxic evidence was found in rats. The incidence of pruritus and nausea was significantly lower in the epidural ondansetron group than in the intravenous ondansetron group at 24 and 48 h postoperatively.ConclusionsEpidural ondansetron is more effective in preventing postoperative pruritus and nausea than intravenous ondansetron.

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