• Anaesthesia · Jun 2001

    Randomized Controlled Trial Clinical Trial

    Minimum local analgesic dose of plain ropivacaine vs. ropivacaine combined with sufentanil during epidural analgesia for labour.

    • S Palm, W Gertzen, T Ledowski, M Gleim, and H Wulf.
    • Clinic for Anaesthesiology and Intensive Care Medicine, Christian-Albrechts-University Kiel, Schwanenweg 21, D-24105 Kiel, Germany. palm@anaesthesie.uni-kiel.de
    • Anaesthesia. 2001 Jun 1;56(6):526-9.

    AbstractWe have used the up-and-down allocation technique to assess the relative analgesic potencies of epidural ropivacaine alone and ropivacaine combined with sufentanil 0.75 microg.ml-1 in 42 women requesting epidural analgesia in the first stage of labour. Parturients were randomly allocated to one of the two epidural solutions in a double-blind manner. The concentration of local anaesthetic was determined by the response of the previous parturient: an effective concentration (pain < or = 10 mm on a 10-cm visual analogue pain score within 30 min) resulted in a 0.01% decrease in the concentration of ropivacaine for the next parturient, an ineffective concentration resulted in a 0.01% increase. Minimum local analgesic concentration of ropivacaine alone was 0.13% (95% CI 0.12-0.13%) compared with 0.09% (95% CI 0.08-0.1%) for ropivacaine with sufentanil (p < 0.00001).

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