• Indian J. Exp. Biol. · Mar 1998

    Central nervous system depressant activities of melatonin in rats and mice.

    • A V Shaji and S K Kulkarni.
    • Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
    • Indian J. Exp. Biol. 1998 Mar 1;36(3):257-63.

    AbstractMelatonin (10 and 20 mg/kg) potentiated pentobarbitone (45 mg/kg) induced hypnosis; it (50 and 100 mg/kg) decreased both total and ambulatory activity; produced (10, 25 and 50 mg/kg) hypothermia and possessed (10-400 mg/kg) significant analgesic property both in tail-flick and acetic acid-induced writhing tests. Melatonin in low dose (10 mg/kg) significantly reduced the forced-swimming induced immobility period per se and also reserpine induced immobility. While the antinociceptive effect of melatonin was sensitive to reversal by naloxone (2 mg/kg), other CNS depressant profile resembled the effects of benzodiazepines.

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