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Pulmonary pharmacology · Oct 1996
The role of capsaicin-sensitive C-fibre afferent nerves in the cough reflex.
- J A Karlsson.
- Dagenham Research Centre, Rhone-Poulenc Rorer Central Research, Dagenham, Essex, UK.
- Pulm Pharmacol. 1996 Oct 1;9(5-6):315-21.
AbstractWhile airway rapidly adapting receptors can mediate the cough reflex, much evidence suggests that bronchial C-fibre receptors are also involved in guinea-pigs and man. In man local and systemic C-fibre stimulants have a potent tussive action, which is blocked by low doses of local anaesthetics which leave the reflex bronchoconstriction intact. In guinea-pigs destruction of airway C-fibre receptors by large doses of capsaicin abolishes the cough reflex due to capsaicin and citric acid. Thus there may be subpopulations of airway C-fibres responsible for the different reflexes such as apnoea, cough and bronchoconstriction. The evidence for the role of C-fibre receptors in cough is described and discussed.
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