• Naoki Inui, Noriyuki Enomoto, Takafumi Suda, Yasunori Kageyama, Hiroshi Watanabe, and Kingo Chida.
• The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan. inui@hama-med.ac.jp
• Clin. Biochem. 2008 Sep 1;41(13):1074-7.

ObjectiveAnti-cyclic citrullinated peptide (anti-CCP) antibodies are highly specific markers for rheumatoid arthritis (RA) and useful for predicting RA development and progression. However, it has not been fully determined whether anti-CCP antibodies are associated with pulmonary diseases in RA patients. In the present study, we aimed to elucidate the relationships between anti-CCP antibodies and pulmonary diseases, particularly interstitial lung disease (ILD) and bronchiolitis.Design And MethodsUsing an enzyme-linked immunosorbent assay, the presence of serum anti-CCP antibodies was examined in 18 RA patients with ILD and bronchiolitis who were diagnosed based on pathologic findings. A further 36 RA subjects without any pulmonary diseases served as a reference population.ResultsNo significant differences were found for the prevalences and levels of anti-CCP antibodies between patients with and without ILD and follicular bronchiolitis.ConclusionDetection of serum anti-CCP antibodies has no association with pulmonary diseases in RA patients.

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