• Tech Vasc Interv Radiol · Mar 2012

    Review

    Intra-arterial thrombolysis: tissue plasminogen activator and other thrombolytic agents.

    • Edgar A Samaniego, Italo Linfante, and Guilherme Dabus.
    • Department of NeuroInterventional Surgery, Baptist Cardiac and Vascular Institute, Miami, FL 33176, USA.
    • Tech Vasc Interv Radiol. 2012 Mar 1;15(1):41-6.

    AbstractRecanalization rates with the administration of intravenous tissue plasminogen activator in acute ischemic stroke are low. Adjuvant endovascular techniques that achieve recanalization by direct intra-arterial (IA) delivery of thrombolytics, mechanical clot retrieval, clot aspiration, and stenting may complement intravenous pharmacotherapy. IA thrombolytics can be administered within 6 hours of symptom onset in anterior circulation strokes and within 24 hours in posterior circulation strokes. This review describes the indications, patient selection, and technique for IA administration of thrombolytics.Copyright © 2012 Elsevier Inc. All rights reserved.

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