• Francisco Manzano, Ana M Pérez-Pérez, Susana Martínez-Ruiz, Cristina Garrido-Colmenero, Delphine Roldan, María Del Mar Jiménez-Quintana, Emilio Sánchez-Cantalejo, and Manuel Colmenero.
• Intensive Care Unit, Hospital Universitario Virgen de las Nieves, Granada, Spain.
• J Eval Clin Pract. 2014 Aug 1;20(4):362-8.

Rationale, Aims And ObjectivesPressure ulcers (PUs) are a common and serious complication in critically ill patients. The aim of this study was to evaluate the relationship between the development of a PU and hospital mortality in patients requiring mechanical ventilation (MV) in an intensive care unit (ICU).MethodsA prospective cohort study was performed over two years in patients requiring MV for ≥ 24 hours in a medical-surgical ICU. Primary outcome measure was hospital mortality and main independent variable was the development of a PU grade ≥ II. Hazard ratios (HRs) were calculated using a Cox model with time-dependent covariates.ResultsOut of 563 patients in the study, 110 (19.5%) developed a PU. Overall hospital mortality was 48.7%. In the adjusted multivariate model, PU onset was a significant independent predictor of mortality (adjusted HR, 1.28; 95% confidence interval, 1.003-1.65; P = 0.047). The model also included the Acute Physiology and Chronic Health Evaluation II score, total Sequential Organ Failure Assessment on day 3, hepatic cirrhosis and medical admission.ConclusionWithin the limitations of a single-centre approach, PU development appears to be associated with an increase in mortality among patients requiring MV for 24 hours or longer.© 2014 John Wiley & Sons, Ltd.

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