• Jui-An Lin, Chun-Chang Yeh, Meei-Shyuan Lee, Ching-Tang Wu, Shinn-Long Lin, and Chih-Shung Wong.
• Department of Anesthesiology, Tri-Service General Hospital and National Defense Medical Center, National Defense University, #325 Chenggung Road Section 2, Neihu 114, Taipei, Taiwan, Republic of China.
• Anesth. Analg. 2005 Sep 1;101(3):670-4, table of contents.

AbstractWe designed this study to evaluate the effect of injection time and smoking on fentanyl-induced cough. Four-hundred-fifty ASA class I-II patients, aged 18-80 yr and weighing 40-90 kg, scheduled for elective surgery were included. All patients received fentanyl (100 microg for patients weighing 40-69 kg and 150 microg for patients weighing 70-90 kg for clinical convenience) via the proximal port of a peripheral IV line on the forearm. Patients were randomly assigned to 3 groups of 150 patients each. Patients in Group I received fentanyl injection over 2 s, whereas for patients in Groups II and III the fentanyl was injected at a constant rate over 15 s and 30 s, respectively. We recorded the number of coughs of each patient during and 30 s after fentanyl injection. The incidence of cough was 18% in group I, 8% in Group II, and 1.3% in Group III, significantly less (P < 0.05) with a longer injection time. Current smokers had a less frequent incidence of cough than nonsmokers; however, this effect was only significant in light smokers (<10 cigarettes per day or <10 smoking years or <10 pack-years). In conclusion, a longer injection time reduces the incidence of fentanyl-induced cough, and light smoking may be a protective factor against fentanyl-induced cough.

28 keywords...

hide…