• Kazumi Iida, Mariko Handa, Ken-ichi Fukuda, Naoko Saita, Masataka Kasahara, Yoshihiko Koukita, Akiko Urabe, Masakazu Hayashida, Tatsuya Ichinohe, and Yuzuru Kaneko.
• Department of Oral Health and Clinical Science, Division of Dental Anesthesiology, Suidoubashi Hospital Dental Anesthesia/Orofacial Pain Center, Tokyo 160-0023.
• Masui. 2009 Aug 1;58(8):962-5.

BackgroundIV fentanyl en bolus can provoke cough reflex. We evaluated the effects of the IV fentanyl dose on the incidence and onset time of fentanyl-induced cough.MethodsTree hundred and eighteen ASA physical status I - II patients scheduled for oral surgery under general anesthesia were randomly assigned to receive 1 microg x kg(-1), 3 microg x kg(-1) or 5 microg x kg(-1) of IV fentanyl (n = 106 for each group). We recorded, in each patient, presence/absence and onset time, if present, of cough reflex for 60 seconds after fentanyl injection.ResultsThe incidences of fentanyl-induced cough were 6.6%, 22.5%, and 44.3% in the 1 microg x kg(-1), 3 microg x kg(-1), and 5 microg x kg(-1) groups, respectively. The onset times of fentanyl-induced cough were 29.0 +/- 11.8 seconds, 22.5 +/- 7.9 seconds, and 19.5 +/- 7.0 seconds in the 1 microg x kg(-1), 3 microg x kg(-1), and 5 microg x kg(-1) groups, respectively.ConclusionsThe results indicated that the incidence of fentanyl-induced cough increased, and the onset time decreased, with the increasing dose of fentanyl.

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