• Clin. Auton. Res. · Sep 1995

    Case Reports

    Central sympathetic dysregulation and immunological abnormalities in a case of progressive facial hemiatrophy (Parry-Romberg disease).

    • P Lonchampt, J Emile, M C Pélier-Cady, B Cadou, and A Barthelaix.
    • Laboratory of Clinical Electrophysiology, Regional Hospital, Angers, France.
    • Clin. Auton. Res. 1995 Sep 1;5(4):199-204.

    AbstractA case of hemifacial atrophy (Parry-Romberg disease) is discussed. Electrophysiological and immunological studies were performed. Electromyography, blink reflex and trigeminal evoked potential abnormalities indicate that the brain stem may be implicated in the aetiology of the disease. Immunological evidence favoured this possibility and demonstrated possible involvement of the noradrenergic system. Hyperactivity of the brain stem sympathetic centres, possibly caused by an autoimmune process, may be the primary cause of the cutaneous and subcutaneous atrophy in Parry-Romberg disease.

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