• J. Neurol. Sci. · Apr 2012

    Review

    Post-cardiac arrest brain injury: pathophysiology and treatment.

    • Athanasios Chalkias and Theodoros Xanthos.
    • National and Kapodistrian University of Athens, Medical School, Department of Anatomy, Greece. thanoschalkias@yahoo.gr
    • J. Neurol. Sci. 2012 Apr 15;315(1-2):1-8.

    AbstractCardiac arrest is a leading cause of death that affects more than a million individuals worldwide every year. Despite the recent advancement in the field of cardiac arrest and resuscitation, the management and prognosis of post-cardiac arrest brain injury remain suboptimal. The pathophysiology of post-cardiac arrest brain injury involves a complex cascade of molecular events, most of which remain unknown. Considering that a potentially broad therapeutic window for neuroprotective drug therapy is offered in most successfully resuscitated patient after cardiac arrest, the need for further research is imperative. The aim of this article is to present the major pathophysiological disturbances leading to post-cardiac arrest brain injury, as well as to review the available pharmacological therapies.Copyright © 2011 Elsevier B.V. All rights reserved.

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