• Aysu Inan Kocum, Mesut Sener, Esra Caliskan, Nesrin Bozdogan, Deniz Micozkadioglu, Ismail Yilmaz, and Anis Aribogan.
• Departamento de Anestesiologia e Reanimação, Universidade Baskent, Turkey.
• Braz J Otorhinolaryngol. 2013 Jan 1;79(1):89-94.

UnlabelledTonsillectomy is associated with severe postoperative pain for which, several drugs are employed for management.ObjectiveIn this double-blind, placebo-controlled study we aimed to evaluate the efficacy of intravenous paracetamol and dipyrone when used for post-tonsillectomy analgesia in children.Method120 children aged 3-6 yr, undergoing tonsillectomy with or without adenoidectomy and/or ventilation tube insertion were randomized to receive intraoperative infusions of paracetamol (15 mg/kg), dipyrone (15 mg/kg) or placebo (0.9% NaCl). Evaluation was carried out at 0.25, 0.50, 1, 2, 4, 6h postoperatively. Pethidine 0.25 mg/kg was utilized as rescue analgesic. Cumulative pethidine requirement was the primary outcome. Pain intensity measurement, pain relief, sedation level, nausea and vomiting, postoperative bleeding and any other adverse effects were noted.ResultsNo significant difference was found in pethidine requirement between paracetamol and dipyrone groups. Cumulative pethidine requirement was significantly less in paracetamol and dipyrone groups vs. placebo. No significant difference was observed between groups in postoperative pain intensity scores throughout the study.ConclusionIntravenous paracetamol is found to have a similar analgesic efficacy as intravenous dipyrone and they both help to reduce the opioid requirement for postoperative analgesia in pediatric day-case tonsillectomy.

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