• René Handschu, Mathias Haslbeck, Alexandra Hartmann, Andreas Fellgiebel, Peter Kolominsky-Rabas, Dietmar Schneider, Jörg Berrouschot, Frank Erbguth, and Udo Reulbach.
• Dept. of Neurology, Friedrich-Alexander-Universitaet, Schwabachanlage 6, 91054 Erlangen, Germany. rene.handschu@neuro.med.uni-erlangen.de
• J. Neurol. 2005 Oct 1;252(10):1249-54.

Background And PurposeThe use of early prognostic data provided by various scores in critically ill stroke patients remains unclear. We tested the performance of the Simplified Acute Physiology Score (SAPS) II in prediction of mortality of acute stroke patients in the NeuroCriticalCareUnit (NCCU).MethodsDuring one year every patient admitted to the NCCUs at 2 University hospitals for cerebral ischemia (CI) or intracerebral hemorrhage (ICH) and intubated was included in this study. Data for SAPS (I)/II and the Glasgow Coma Scale (GCS) were collected, and mortality at 10 days, 90 days and 1 year was determined. Prognostic performance of all scores was tested by calculation of receiver operating curve (ROC) and by Cox regression analysis.Results90 patients were included in the study, 49 with ICH and 41 with CI. Mortality after 10 days was 32.2%, after 3 months 58.9% and after 1 year 67.8%. Compared by their area under curve the predictive values were overall quite good for both SAPS (I) (0.77) and SAPS II (0.77) as well as GCS. Motor subscore was equal to total GCS (0.75 vs. 0.73). In Cox regression models all three scores were independent predictors of fatal outcome.ConclusionSAPS II and SAPS (I) but also the GCS are valuable tools for prediction of short and long-term mortality in acute stroke patients treated in NCCU. The GCS as a predictor for mortality in stroke patients could be further simplified by using its subscore "best motor response" alone.

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