• Australas. J. Dermatol. · May 2007

    Case Reports

    Use of infliximab in pyoderma gangrenosum.

    • Daniel Hewitt and Clare Tait.
    • Department of Dermatology, Royal Perth Hospital, Western Australia, Australia. dthewitt@gmail.com
    • Australas. J. Dermatol. 2007 May 1;48(2):95-8.

    AbstractA 57-year-old man, with a 2-year history of Crohn's disease, presented with a rapidly progressive abdominal ulcer. It was clinically and histologically consistent with pyoderma gangrenosum but it did not respond to either high-dose oral prednisolone or intravenous hydrocortisone. Infliximab resulted in an early, dramatic and sustained improvement. His bowel symptoms, which flared a few weeks prior to the onset of pyoderma gangrenosum, only partially improved. Despite six infliximab infusions, the inflammatory bowel disease is poorly controlled, whereas the pyoderma gangrenosum remains healed.

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