• Connecticut medicine · Feb 2015

    Goal-Directed Therapy for Sepsis: Has the Beast Been Slain or Do Questions Remain?

    • Charles R Wira and Kai Swenson.
    • Conn Med. 2015 Feb 1;79(2):97-9.

    AbstractThe identification and early management of severe sepsis and septic shock has undergone a significant evolution over the past decade and a half. Recently two large multicentered trials were published contradicting the original Early-Goal Directed Therapy (EGDT) trial published in 2001. In this commentary we evaluate the current trials place in the historical context of negative and positive trial's on EGDT sepsis resuscitation.

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