• Clin. Pharmacol. Ther. · Feb 2015

    Angiotensin II type 2-receptor: new clinically validated target in the treatment of neuropathic pain.

    • A S C Rice and M T Smith.
    • Department of Surgery and Cancer, Imperial College London, London, SW10 9NH, UK.
    • Clin. Pharmacol. Ther. 2015 Feb 1;97(2):128-30.

    AbstractNeuropathic pain is a large unmet medical need. The angiotensin II type 2 (AT2 ) receptor is a target with promising data in rodent models of peripheral neuropathic pain. The AT2 receptor has attracted attention on the basis of human data from a proof-of-concept clinical trial showing that oral EMA401, a highly selective, peripherally restricted, small molecule AT2 receptor antagonist, at 100 mg twice-daily for 4 weeks, alleviated postherpetic neuralgia, an often intractable type of peripheral neuropathic pain.© 2014 American Society for Clinical Pharmacology and Therapeutics.

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