• Anaesthesia · Mar 1995

    Randomized Controlled Trial Clinical Trial

    The effect of midazolam premedication on implicit memory activation during alfentanil-nitrous oxide anaesthesia.

    • A De Roode, M Jelicic, B Bonke, and J G Bovill.
    • Department of Anaesthesiology, University Hospital of Leiden, The Netherlands.
    • Anaesthesia. 1995 Mar 1;50(3):191-4.

    AbstractEighty-three patients were given midazolam 0.1 mg.kg-1 by intramuscular injection as premedication before general anaesthesia with alfentanil-nitrous oxide. During anaesthesia patients were presented (through headphones) with either statements about common facts of some years ago (group A) (n = 43) or new verbal associations, e.g. names of fictitious, nonfamous people (group B) (n = 40). In a previous study with the same anaesthetic technique, but without premedication there was significant activation of implicit memory (p < 0.001). In this study we found no explicit or implicit memory for the auditory information presented during anaesthesia. Midazolam premedication can prevent implicit memory activation during alfentanil-nitrous oxide anaesthesia.

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