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- Jordan M Raymer, Lisa M Flynn, and Ronald F Martin.
- Department of Surgery, Marshfield Clinic and Saint Joseph's Hospital, Marshfield, WI 54449, USA.
- Surg. Clin. North Am. 2012 Apr 1;92(2):221-34, vii.
AbstractHemorrhage remains a leading cause of morbidity and death in both civilian and military trauma. Restoration of effective end-organ perfusion by stopping hemorrhage and restoring intravascular volume in such a way as to minimize acidosis, hypothermia, and coagulopathy, almost always requires the use of blood and/or blood-component therapy. The best method to manage life-threatening hemorrhage is to avoid the circumstance that prompted it or to mitigate blood loss early in the injury cycle; otherwise, blood replacement must suffice. This article reviews current understanding of massive transfusion, along with its attendant unintended consequences, in the management of patients with profound hemorrhage.Copyright © 2012 Elsevier Inc. All rights reserved.
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