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Annals of neurology · Apr 2014
Botulinum toxin-A treatment reduces human mechanical pain sensitivity and mechanotransduction.
- Kathryn Paterson, Stéphane Lolignier, John N Wood, Stephen B McMahon, and David L H Bennett.
- Wolfson Centre for Age-Related Disease, King's College London, London.
- Ann. Neurol. 2014 Apr 1;75(4):591-6.
AbstractThe mechanisms underlying the analgesic effects of botulinum toxin serotype A (BoNT-A) are not well understood. We have tested the hypothesis that BoNT-A can block nociceptor transduction. Intradermal administration of BoNT-A to healthy volunteers produced a marked and specific decrease in noxious mechanical pain sensitivity, whereas sensitivity to low-threshold mechanical and thermal stimuli was unchanged. BoNT-A did not affect cutaneous innervation. In cultured rodent primary sensory neurons, BoNT-A decreased the proportion of neurons expressing slowly adapting mechanically gated currents linked to mechanical pain transduction. Inhibition of mechanotransduction provides a novel locus of action of BoNT-A, further understanding of which may extend its use as an analgesic agent.© 2014 The Authors. American Neurological Association.
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