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Acta endocrinologica · May 1990
Comparative StudyContractile effect of oxytocin and 1-deamino-1-carba-2-tyrosine (0-methyl)-oxytocin in myometrial tissue from non-pregnant and term pregnant women.
- A Norström, A Andersson, and H Vilhardt.
- Department of Obstetrics and Gynecology, University of Göteborg, Sahlgren's Hospital, Sweden.
- Acta Endocrinol. 1990 May 1;122(5):566-8.
AbstractThe contractile effect of the analogue 1-deamino-1-carba-2-tyrosine (0-methyl)-oxytocin (carbetocin) on isolated strips from the human myometrium was compared with that of oxytocin. Neither oxytocin nor carbetocin affected contractile activity in strips from non-pregnant women, but both peptides stimulated contractile activity in strips from women at term pregnancy (2 x 10(-11) mol/l, and 10(-10) mol/l, respectively). Thus, carbetocin is almost as potent as oxytocin with regard to stimulating myometrial contractions at term.
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