• Anesthesiology · Sep 2011

    Review

    Reducing noninfectious risks of blood transfusion.

    • Brian M Gilliss, Mark R Looney, and Michael A Gropper.
    • Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143-0624, USA.
    • Anesthesiology. 2011 Sep 1; 115 (3): 635649635-49.

    AbstractAs screening for transfusion-associated infections has improved, noninfectious complications of transfusion now cause the majority of morbidity and mortality associated with transfusion in the United States. For example, transfusion-related acute lung injury, transfusion-associated circulatory overload, and hemolytic transfusion-reactions are the first, second, and third leading causes of death from transfusion, respectively. These complications and others are reviewed, and several controversial methods for prevention of noninfectious complications of transfusion are discussed, including universal leukoreduction of erythrocyte units, use of male-only plasma, and restriction of erythrocyte storage age.

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