• Ilker Inanc Balkan, Mustafa Dogan, Bulent Durdu, Ayse Batirel, Ismail N Hakyemez, Birsen Cetin, Oguz Karabay, Ibak Gonen, Ahmet Selim Ozkan, Sami Uzun, Muhammed Emin Demirkol, Sedat Akbas, Asiye Bahar Kacmaz, Sukru Aras, Ali Mert, and Fehmi Tabak.
• From the 1 Department of Infectious Diseases and Clinical Microbiology, Istanbul University Cerrahpasa School of Medicine , Istanbul.
• Scand. J. Infect. Dis. 2014 Oct 1;46(10):678-85.

BackgroundColistin (COL) has become the backbone of the treatment of infections due to extensively drug-resistant (XDR) Gram-negative bacteria. The most common restriction to its use is acute kidney injury (AKI).MethodsWe conducted a retrospective cohort study to evaluate risk factors for new-onset AKI in patients receiving COL. The cohort consisted of 198 adults admitted to 9 referral hospitals between January 2010 and October 2012 and treated with intravenous COL for ≥ 72 h. Patients with no pre-existing kidney dysfunction were compared in terms of risk factors and outcomes of AKI graded according to the RIFLE criteria. Logistic regression analysis was used to identify associated risk factors.ResultsA total of 198 patients met the inclusion criteria, of whom 167 had no pre-existing kidney dysfunction; the mean patient age was 58.77 (± 18.98) y. Bloodstream infections (34.8%) and ventilator-associated pneumonia (32.3%) were the 2 most common indications for COL use. New-onset AKI developed in 46.1% of the patients, graded as risk (10%), injury (15%), and failure (21%). Patients with high Charlson co-morbidity index (CCI) scores (p = 0.001) and comparatively low initial glomerular filtration rate (GFR) estimations (p < 0.001) were more likely to develop AKI, but older age (p = 0.001; odds ratio 5.199, 95% confidence interval 2.684-10.072) was the major predictor in the multivariate analysis. In-hospital recovery from AKI occurred in 58.1%, within a median of 7 days.ConclusionsCOL-induced nephrotoxicity occurred significantly more often in patients older than 60 y of age and was related to low initial GFR estimations and high CCI scores, which were basically determined by age.

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