• Michelle E M H Westerhuis, Martina M Porath, Jeroen H Becker, Eline S A Van Den Akker, Erik Van Beek, Hendrikus J H M Van Dessel, Addy P Drogtrop, Herman P Van Geijn, Giuseppi C M Graziosi, Floris Groenendaal, Jan M M Van Lith, Ben Willem J Mol, Karel G M Moons, Jan G Nijhuis, Swan G Oei, Herman P Oosterbaan, Robbert J P Rijnders, Nico W E Schuitemaker, Lia D E Wijnberger, Christine Willekes, Maurice G A J Wouters, Gerard H A Visser, and Anneke Kwee.
• Department of Obstetrics and Gynaecology, University Medical Center Utrecht, Utrecht, the Netherlands. m.e.m.h.westerhuis@umcutrecht.nl
• Acta Obstet Gynecol Scand. 2012 Jul 1;91(7):830-7.

ObjectiveTo evaluate whether correct adherence to clinical guidelines might have led to prevention of cases with adverse neonatal outcome.DesignSecondary analysis of cases with adverse outcome in a multicenter randomized clinical trial.SettingNine Dutch hospitals.PopulationPregnant women with a term singleton fetus in cephalic position.MethodsData were obtained from a randomized trial that compared monitoring by STAN® (index group) with cardiotocography (control group). In both trial arms, three observers independently assessed the fetal surveillance results in all cases with adverse neonatal outcome, to determine whether an indication for intervention was present, based on current clinical guidelines.Main Outcome MeasuresAdverse neonatal outcome cases fulfilled one or more of the following criteria: (i) metabolic acidosis in umbilical cord artery (pH < 7.05 and base deficit in extracellular fluid >12 mmol/L); (ii) umbilical cord artery pH < 7.00; (iii) perinatal death; and/or (iv) signs of moderate or severe hypoxic ischemic encephalopathy.ResultsWe studied 5681 women, of whom 61 (1.1%) had an adverse outcome (26 index; 35 control). In these women, the number of performed operative deliveries for fetal distress was 18 (69.2%) and 16 (45.7%), respectively. Reassessment of all 61 cases showed that there was a fetal indication to intervene in 23 (88.5%) and 19 (57.6%) cases, respectively. In 13 (50.0%) vs. 11 (33.3%) cases, respectively, this indication occurred more than 20 min before the time of delivery, meaning that these adverse outcomes could possibly have been prevented.ConclusionsIn our trial, more strict adherence to clinical guidelines could have led to additional identification and prevention of adverse outcome.© 2012 The Authors Acta Obstetricia et Gynecologica Scandinavica© 2012 Nordic Federation of Societies of Obstetrics and Gynecology.

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