• Cancer letters · Nov 2013

    Review

    Cancer genome sequencing: understanding malignancy as a disease of the genome, its conformation, and its evolution.

    • Lalit R Patel, Matti Nykter, Kexin Chen, and Wei Zhang.
    • The University of Texas Health Science Center, Houston, TX, USA; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    • Cancer Lett. 2013 Nov 1;340(2):152-60.

    AbstractAdvances in cancer genomics have been propelled by the steady evolution of molecular profiling technologies. Over the past decade, high-throughput sequencing technologies have matured to the point necessary to support disease-specific shotgun sequencing. This has compelled whole-genome sequencing studies across a broad panel of malignancies. The emergence of high-throughput sequencing technologies has inspired new chemical and computational techniques enabling interrogation of cancer-specific genomic and transcriptomic variants, previously unannotated genes, and chromatin structure. Finally, recent progress in single-cell sequencing holds great promise for studies interrogating the consequences of tumor evolution in cancers presenting with genomic heterogeneity.Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

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