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Semin Respir Crit Care Med · Aug 2013
ReviewTreatment of acute lung injury: current and emerging pharmacological therapies.
- Sweeney Rob Mac RM Centre for Infection and Immunity, Queen's University Belfast, Northern Ireland, United Kingdom., Mark Griffiths, and Danny McAuley.
- Centre for Infection and Immunity, Queen's University Belfast, Northern Ireland, United Kingdom.
- Semin Respir Crit Care Med. 2013 Aug 1; 34 (4): 487-98.
AbstractAs a syndrome of injurious pulmonary inflammation resulting in deranged respiratory physiology, acute lung injury affords numerous potential therapeutic targets. Two main pharmacological treatment strategies have arisen-the attempted inhibition of excessive inflammation or the manipulation of the resulting physiological derangement causing respiratory failure. Additionally, such interventions may allow the delivery of less injurious mechanical ventilation. An emerging approach is the use of cell-based therapy, which, rather than inhibiting the inflammatory process, seeks to convert it from an injurious process to a reparative one. This review outlines previous, current, and emerging pharmacological therapies for acute lung injury. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
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