• Med. J. Malaysia · Aug 2011

    Randomized Controlled Trial Comparative Study

    Intravenous ketamine is as effective as midazolam/fentanyl for procedural sedation and analgesia in the emergency department.

    • S M Jamal, S M Fathil, M M Nidzwani, A K Ismail, and F M Yatim.
    • Emergency Department, Medical Faculty, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latiff, Cheras, 56000 Kuala Lumpur, Malaysia. suriazwa@gmail.com
    • Med. J. Malaysia. 2011 Aug 1;66(3):231-3.

    AbstractThe study compared the effectiveness of ketamine and midazolam/fentanyl as procedural sedation and analgesia agents for reduction of fractures and dislocated joints. Forty-one adult patients were enrolled by convenience sampling. They were randomized to receive ketamine or midazolam/fentanyl. Depth of sedation, pain score, procedural outcome and memory of the procedure were documented. The ketamine group had deeper sedation, but there was no statistical difference in other variables between the two groups. Three patients in the midazolam/fentanyl group had oxygen desaturation. More adverse effects were associated with ketamine. Intravenous ketamine is as effective as midazolam/fentanyl for procedural sedation.

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