• Julien Guihaire, Harm Jan Bogaard, Erwan Flécher, Pierre-Emmanuel Noly, Olaf Mercier, François Haddad, and Elie Fadel.
• Laboratory of Surgical Research, Marie Lannelongue Hospital, University of Paris Sud, Le Plessis Robinson, France.
• Semin Respir Crit Care Med. 2013 Oct 1; 34 (5): 689-99.

AbstractThe right ventricle (RV) faces major changes in loading conditions associated with cardiovascular and pulmonary vascular disorders. Despite major pharmacological advances since the last decade, pulmonary arterial hypertension remains a deadly disease mainly secondary to the development of right ventricular failure (RVF). Several experimental models of RVF have been developed over the past three decades providing a particular insight in RV pathophysiology. Mechanisms involved in the transition from RV adaptive hypertrophy to maladaptive remodeling and failure in conditions of chronic RV pressure or volume overload are of a great interest but not yet completely understood. Further investigations are needed to find new therapeutic approaches for RVF. Current animal models and emerging concepts of translational RV research will be detailed in this review. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

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