• Critical care clinics · Oct 2011

    Review

    Heparin-induced thrombocytopenia in critically ill patients.

    • Theodore E Warkentin.
    • Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada. twarken@mcmaster.ca
    • Crit Care Clin. 2011 Oct 1;27(4):805-23, v.

    AbstractCritically ill patients commonly evince thrombocytopenia, either evident on admission to the intensive care unit (ICU) or that develops during their stay. Heparin-induced thrombocytopenia (HIT) explains thrombocytopenia in only approximately 1/100 critically ill patients; also, only 1 or 2 in 10 ICU patients with a positive PF4-dependent enzyme immunoassay has “true” HIT. Thus, there is major potential for overdiagnosis of HIT in the ICU. A recent study showing that dalteparin is associated with a reduced frequency of HIT indicates that critically ill patients too can benefit from the HIT-reducing potential of this low molecular weight heparin preparation.

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