• Zhonghua yi xue za zhi · Oct 2010

    Randomized Controlled Trial

    [Application study of periarticular multimodal drug injection in total knee arthroplasty].

    • Wen-wei Qian, Xi-sheng Weng, Qi Fei, Ye Li, Ji-liang Zhai, and Yan-yan Bian.
    • Department of Orthopedics, Peking Union Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. qww007@sohu.com
    • Zhonghua Yi Xue Za Zhi. 2010 Oct 12;90(37):2593-6.

    ObjectiveTo investigate and compare the analgesic effect of a periarticular multimodal drug injection and patient-controlled epidural analgesia (PCEA) in total knee arthroplasty (TKA).MethodsThirty-six patients undergoing unilateral TKA were randomly divided into two groups (A and B). Group A received a periarticular injection of ropivacaine, morphine and epinephrine at operation and Group B did not. All patients received postoperative patient-controlled epidural analgesia (PCEA). Preoperative baseline data, surgery-related conditions, postoperative VAS (visual analog score), range of motion (ROM), time of opening PCEA, drug dosage in PCEA and side effects were recorded respectively.ResultsAt 6, 12 hour VAS in Group A was lower than Group B (P < 0.05). The time of opening PCEA in Group A was longer than Group B (P < 0.05). The drug dosage in PCEA in Group A was less than Group B (P < 0.05). There was no difference of surgical conditions, ROM, 24/48 hour VAS and side effects between two groups (P > 0.05).ConclusionPeriarticular drug injection during TKA can relieve pain early after TKA, prolong the time of opening PCEA and reduce the drug dosage in PCEA.

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