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Critical care clinics · Jul 2009
ReviewPharmacology of commonly used analgesics and sedatives in the ICU: benzodiazepines, propofol, and opioids.
- John W Devlin and Russel J Roberts.
- Northeastern University School of Pharmacy, MU206, 360 Huntington Avenue, Boston, MA 02115, USA. j.devlin@neu.edu
- Crit Care Clin. 2009 Jul 1;25(3):431-49, vii.
AbstractOpioids, benzodiazepines, and propofol remain the mainstay by which to optimize patient comfort and facilitate mechanical ventilation in patients who are critically ill. Unfortunately none of these agents share all of the characteristics of the ideal sedative or analgesic agent: rapid onset, rapid recovery, a predictable dose response, a lack of drug accumulation, and no toxicity. To optimize care, critical care clinicians should be familiar with the many pharmacokinetic, pharmacodynamic, and pharmacogenetic variables that can affect the safety and efficacy of these sedatives and analgesics.
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