• Masui · May 2010

    [Antiemetic-induced extrapyramidal symptoms seen by our palliative care team].

    • Ryuichi Nakanuno, Taishin Ito, Aki Matsunaga, and Masashi Kawamoto.
    • Department of Anesthesiology and Critical Care, Hiroshima University Hospital, Hiroshima 734-8551.
    • Masui. 2010 May 1;59(5):645-7.

    BackgroundAntiemetic drugs, which are usually prescribed with opioids, occasionally induce extrapyramidal symptoms(EPS).MethodsIn 109 patients treated with our palliative care team, we retrospectively investigated the appearance of antiemetic-induced EPS; its incidence, latent period, onset age, symptoms, causing agents and clinical outcomes.ResultsEPS were observed in 6 of 109 patients. Six EPS patients, 2 men and 4 women, were between the age of 53 and 66 years. Prochlorperazine was used in all EPS patients. Two EPS were induced with unnecessary antiemetic drugs. Onset of EPS was from 11 to 162 days after beginning of antiemetic drugs. There were 5 patients with slow movement or speech, 3 patients with expressionless face, 2 patients with akathisia, and one patient with dysphagia. Five EPS patients were improved by using biperiden and one patient was by changing prochlorperazine to perospirone.ConclusionsEPS were found in 6 of 109 patients during palliative care. We concluded that it was important not to forget the appearance of antiemetic-induced EPS when prescribing antiemetic drugs in palliative

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