• Sana M Al-Khatib, Gail Hafley, Kerry L Lee, and Alfred E Buxton.
• 1 Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA.
• Europace. 2010 Aug 1;12(8):1112-8.

AimsWe sought to assess the relation between time from myocardial infarction (MI) to enrolment and patient outcomes and to examine the association between these outcomes and implantable cardioverter defibrillator (ICD) therapy.Methods And ResultsWe analysed the Multicenter UnSustained Tachycardia Trial database (n = 1650). In examining all endpoints, Cox proportional hazards models were used to adjust for potential confounders. There was no significant association between time from MI to enrolment and any of the outcomes (P > 0.1). Inducibility by an electrophysiology study (EPS) was associated with a higher risk of arrhythmic death or cardiac arrest [adjusted hazard ratio (HR) 2.51; 95% confidence interval (CI) 1.64-3.84] and all-cause death (adjusted HR 1.45; 95% CI 1.04-2.03) only in patients who had an MI 6 months before enrolment (adjusted HR 0.34; 95% CI 0.21-0.54).ConclusionThe risk of arrhythmic death or cardiac arrest and all-cause death did not vary as a function of time from the most recent MI to enrolment. Inducibility by an EPS was associated with worse outcomes only in patients with an MI

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