• W C Tan, D D Sin, J Bourbeau, P Hernandez, K R Chapman, R Cowie, J M FitzGerald, D D Marciniuk, F Maltais, A S Buist, J Road, J C Hogg, M Kirby, H Coxson, C Hague, J Leipsic, D E O'Donnell, S D Aaron, and CanCOLD Collaborative Research Group.
• University of British Columbia, Heart Lung Innovation, Vancouver, British Columbia, Canada.
• Thorax. 2015 Sep 1;70(9):822-9.

BackgroundThere is limited data on the risk factors and phenotypical characteristics associated with spirometrically confirmed COPD in never-smokers in the general population.AimsTo compare the characteristics associated with COPD by gender and by severity of airway obstruction in never-smokers and in ever-smokers.MethodWe analysed the data from 5176 adults aged 40 years and older who participated in the initial cross-sectional phase of the population-based, prospective, multisite Canadian Cohort of Obstructive Lung Disease study. Never-smokers were defined as those with a lifetime exposure of <1/20 pack year. Logistic regressions were constructed to evaluate associations for 'mild' and 'moderate-severe' COPD defined by FEV1/FVC <5th centile (lower limits of normal). Analyses were performed using SAS V.9.1 (SAS Institute, Cary, North Carolina, USA).ResultsThe prevalence of COPD (FEV1/FVCConclusionsThe study confirmed the substantial burden of COPD among never-smokers, defined the common and gender-specific risk factors for COPD in never-smokers and provided early insight into potential phenotypical differences in COPD between lifelong never-smokers and ever-smokers.Trial Registration NumberNCT00920348 (ClinicalTrials.gov); study ID number: IRO-93326.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

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