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Hospital practice (1995) · Apr 2012
ReviewThe diabetes paradox: diabetes is not independently associated with mortality in critically ill patients.
- James S Krinsley and Molly Fisher.
- Director of Critical Care, Stamford Hospital, Stamford, CT; Clinical Professor of Medicine, Columbia University College of Physicians and Surgeons, New York, NY. jkrinsley@stamhealth.org.
- Hosp Pract (1995). 2012 Apr 1;40(2):31-5.
AbstractIntensive monitoring of blood glucose levels and treatment of hyperglycemia in critically ill patients has become a standard of care over the past decade. Although diabetes is associated with a large burden of illness in outpatients, the "diabetes paradox" suggests that in patients admitted to intensive care units, the presence of diabetes as a comorbidity is not independently associated with increased risk of mortality. This review article 1) describes prospective trial and observational cohort literature addressing this issue, 2) addresses the potential mechanisms underlying the diabetes paradox, and 3) discusses implications for patient care and future research.
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