• Zentralbl Gynakol · Jan 1994

    [Anti-hypertensive therapy in pregnancy-induced hypertension with urapidil].

    • J Wacker, J Müller, E M Grischke, R Unkels, and G Bastert.
    • Frauenklinik, Universität Heidelberg.
    • Zentralbl Gynakol. 1994 Jan 1;116(5):271-3.

    AbstractUrapidil is an antagonist of postsynaptic alpha 1 receptors, which leads to a diminution of the increased blood pressure by reducing the peripheral vascular resistance. With this pilot study we examined, whether it is possible to reduce the pregnancy-induced-hypertension with urapidil postpartum. The postpartum dosage of dihydralazine was diminished step by step and finally discontinued. We started i.v. treatment with urapidil at a diastolic blood pressure of more than 100 mm Hg. We observed a declining blood pressure in all cases without any tachycardia or serious side effects. Further studies will have to classify the rank of urapidil in the treatment of hypertension in preeclampsia.

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