• Seitetsu Kanemura, Noriyuki Ohta, Hidenori Yamanaka, Ryoko Takahashi, Osamu Hirao, Akinori Uchiyama, Yuji Fujino, and Takashi Mashimo.
• Intensive Care Unit, Osaka University Hospital, Osaka 565-0871.
• Masui. 2009 Apr 1;58(4):480-3.

AbstractTransfusion-related acute lung injury (TRALI) is a serious complication of transfusion of blood and blood components. TRALI is reported to be the most common cause of transfusion-associated death. TRALI has increasingly become known in the medical community. However, TRALI has been overlooked frequently because of poor knowledge of medical staffs. We report two cases of TRALI after massive transfusion due to massive bleeding during cardiovascular surgery. In the perioperative period, the diagnosis of TRALI is difficult to make because of coexistence of various factors leading to hypoxia. Thus, in this report, we discuss the management of these two cases focusing upon the differential diagnosis of TRALI.

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