• Critical care clinics · Oct 2012

    Review

    Cocaine intoxication.

    • Janice L Zimmerman.
    • Department of Medicine, Weill Cornell Medical College, New York, NY, USA. janicez@tmhs.org
    • Crit Care Clin. 2012 Oct 1;28(4):517-26.

    AbstractCocaine, a natural alkaloid derived from the coca plant, is one of the most commonly abused illicit drugs. Cocaine is commonly abused by inhalation, nasal insufflation, and intravenous injection, resulting in many adverse effects that ensue from local anesthetic, vasoconstrictive, sympathomimetic, psychoactive, and prothrombotic mechanisms. Cocaine can affect all body systems and the clinical presentation may primarily result from organ toxicity. Among the most severe complications are seizures, hemorrhagic and ischemic strokes, myocardial infarction, aortic dissection, rhabdomyolysis, mesenteric ischemia, acute renal injury and multiple organ failure.Copyright © 2012 Elsevier Inc. All rights reserved.

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