• S Botha, C M T Fourie, R Schutte, J Eugen-Olsen, R Pretorius, and A E Schutte.
• 1Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, SOUTH AFRICA 2Clinical Research Centre 136, Copenhagen University Hospital, Hvidovre, DENMARK 3Research to Advance Quality of Nursing & Midwifery (INSINQ), North-West University, Potchefstroom, SOUTH AFRICA.
• J. Hypertens. 2015 Jun 1;33 Suppl 1:e9.

ObjectiveElevated inflammatory markers such as C-reactive protein (CRP) and interleukin-6 (IL-6) are well-known risk factors for cardiovascular mortality. The less familiar marker, soluble urokinase plasminogen activator receptor (suPAR), is known to predict cancer, infections and all-cause mortality. We determined whether suPAR, CRP and IL-6 are predictive of both all-cause and cardiovascular mortality in a black population, highly burdened by cardiovascular disease and HIV infection.Design And MethodWe included 1 425 black South Africans, of which 208 died within five years after baseline data collection. EDTA plasma biomarker levels were determined, while all-cause and cardiovascular mortality were used as endpoints.ResultsAt baseline suPAR, CRP and IL-6 were higher in non-survivors than in survivors (P < 0.001). SuPAR (HR 1.27, 95% CI 1.09-1.48), IL-6 (HR 1.49, 95% CI 1.24-1.78) and CRP (HR 1.39, 95% CI 1.17-1.65) predicted all-cause mortality, while only suPAR (HR 1.40, 95% CI 1.04-1.87) and IL-6 (HR 1.61, 95% CI 1.10-2.35) predicted cardiovascular mortality. The prognostic value of suPAR was independent of IL-6 and CRP (P<=0.015).(Figure is included in full-text article.)Conclusions: SuPAR predicted both all-cause and cardiovascular mortality, independent of traditional risk factors, HIV and other inflammatory markers, underlining the prognostic value of suPAR in a black population.

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