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Critical care clinics · Oct 2012
ReviewToxigenic and metabolic causes of ketosis and ketoacidotic syndromes.
- Martina M Cartwright, Waddah Hajja, Sofian Al-Khatib, Maryam Hazeghazam, Dharmashree Sreedhar, Rebecca Na Li, Edna Wong-McKinstry, and Richard W Carlson.
- Department of Nutritional Sciences, University of Arizona, Shantz Building, Room 309, Tucson, AZ 85721, USA. drmartinac@mac.com
- Crit Care Clin. 2012 Oct 1; 28 (4): 601-31.
AbstractKetoacidotic syndromes are frequently encountered in acute care medicine. This article focuses on ketosis and ketoacidotic syndromes associated with intoxications, alcohol abuse, starvation, and certain dietary supplements as well as inborn errors of metabolism. Although all of these various processes are characterized by the accumulation of ketone bodies and metabolic acidosis, there are differences in the mechanisms, clinical presentations, and principles of therapy for these heterogeneous disorders. Pathophysiologic mechanisms that account for these disorders are presented, as well as guidance regarding identification and management.Copyright © 2012 Elsevier Inc. All rights reserved.
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