Preventing clostridium difficile infection in the intensive

Critical care clinics · Jan 2013

Review

Preventing clostridium difficile infection in the intensive care unit.

Clostridium difficile is a formidable problem in the twenty-first century. Because of injudicious use of antibiotics, the emergence of the hypervirulent epidemic strain of this organism has been difficult to contain. The NAP1/BI/027 strain causes more-severe disease than other widely prevalent strains and affects patients who were not traditionally thought to be at risk for Clostridium difficile infection. Critically ill patients remain at high risk for this pathogen, and preventive measures, such as meticulous contact precautions, hand hygiene, environmental disinfection, and, most importantly, antibiotic stewardship, are the cornerstones of mitigation in the intensive care unit.

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- Marya D Zilberberg and Andrew F Shorr.
- EviMed Research Group, LLC, Goshen, MA 01032, USA. evimedgroup@gmail.com
- Crit Care Clin. 2013 Jan 1;29(1):11-8.
AbstractClostridium difficile is a formidable problem in the twenty-first century. Because of injudicious use of antibiotics, the emergence of the hypervirulent epidemic strain of this organism has been difficult to contain. The NAP1/BI/027 strain causes more-severe disease than other widely prevalent strains and affects patients who were not traditionally thought to be at risk for Clostridium difficile infection. Critically ill patients remain at high risk for this pathogen, and preventive measures, such as meticulous contact precautions, hand hygiene, environmental disinfection, and, most importantly, antibiotic stewardship, are the cornerstones of mitigation in the intensive care unit.Copyright © 2013 Elsevier Inc. All rights reserved.

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Preventing clostridium difficile infection in the intensive care unit.

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