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J. Korean Med. Sci. · Sep 2013
Association of the catechol-o-methyltransferase gene polymorphisms with Korean autism spectrum disorders.
- Hee Jeong Yoo, In Hee Cho, Mira Park, So Young Yang, and Soon Ae Kim.
- Department of Psychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.
- J. Korean Med. Sci. 2013 Sep 1; 28 (9): 140314061403-6.
AbstractThis study evaluated the family-based genetic association between autism spectrum disorders (ASDs) and 5 single-nucleotide polymorphisms (SNPs) in the catechol-o-methyltransferase gene (COMT), which was found among 151 Korean ASDs family trios (dominant model Z = 2.598, P = 0.009, P FDR = 0.045). We found a statistically significant allele transmission or association in terms of the rs6269 SNP in the ASDs trios. Moreover, in the haplotype analysis, the haplotypes with rs6269 demonstrated significant evidence of an association with ASDs (additive model rs6269-rs4818-rs4680-rs769224 haplotype P = 0.004, P FDR = 0.040). Thus, an association may exist between the variants of the COMT gene and the occurrence of ASDs in Koreans.
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