• James P Bonaparte, Martin Corsten, Michael Odell, and Shaun Kilty.
• Department of Otolaryngology–Head and Neck Surgery, The University of Ottawa, Ottawa, ON.
• J Otolaryngol Head N. 2012 Apr 1;41 Suppl 1:S13-20.

PurposeTo test the hypothesis that using Listerine mouthwash prior to administration of topical nasal lidocaine will result in improved pain and comfort outcomes during flexible nasolaryngoscopy (FNL).DesignRandomized, controlled trial.SubjectsA total of 120 patients were randomized to receive a combination of either treatment or placebo mouthwash followed by treatment or placebo nasal spray prior to an FNL examination.Outcome MeasuresPain and discomfort using a 100 mm visual analogue scale.ResultsThe use of lidocaine significantly reduced pain (p = .011) and discomfort (p = .008) compared to placebo nasal spray. Using Listerine prior to administration of lidocaine resulted in the largest reductions. Patients having an extended nasal examination reported more pain (p = .001) and discomfort (p = .03) levels while demonstrating a greater benefit of topical lidocaine compared to those undergoing a primary laryngeal examination (p < .001).DiscussionUsing Listerine prior to application of lidocaine nasal spray reduces the pain and discomfort of FNL. This effect was most clinically significant in patients undergoing an extended or full bilateral nasal examination.

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