• Kazem Rahimi, Connor A Emdin, and Stephen MacMahon.
• From the Division of Cardiovascular Medicine (K.R.), Nuffield Department of Population Health (C.A.E., S.M.), The George Institute for Global Health, and Oxford Martin School (K.R., C.A.E., S.M.), University of Oxford, Oxford, United Kingdom. kazem.rahimi@georgeinstitute.ox.ac.uk.
• Circ. Res. 2015 Mar 13;116(6):925-36.

AbstractDespite the vast amount of evidence on the benefits of blood pressure lowering accumulated to date, elevated blood pressure is still the leading risk factor for disease and disability worldwide. The purpose of this review is to summarize the epidemiological evidence underpinning the association between blood pressure and a range of conditions. This review focuses on the association between systolic and diastolic blood pressures and the risk of cardiovascular and renal disease. Evidence for and against the existence of a J-shaped curve association between blood pressure and cardiovascular risk, and differences in the predictive power of systolic, diastolic, and pulse pressure, are described. In addition, global and regional trends in blood pressure levels and management of hypertension are reviewed.© 2015 American Heart Association, Inc.

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