• Critical care clinics · Oct 2013

    Review

    Overview of Severe Clostridium difficile Infection.

    • Stephen R Eaton and John E Mazuski.
    • Section of Acute and Critical Care Surgery, Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110-1093, USA.
    • Crit Care Clin. 2013 Oct 1;29(4):827-39.

    AbstractClostridium difficile is an anaerobic, spore-forming, gram-positive bacillus that can produce severe colitis resulting in death. There has been an overall increase in the incidence of Clostridium difficile-associated disease and, particularly, an increase in the more virulent forms of the disease. Treatment of severe C difficile infection includes management of severe sepsis and shock, pathogen-directed antibiotic therapy, and, in selected cases, surgical intervention. Ultimately, prevention is the key to limiting the devastating effects of this microorganism.Copyright © 2013 Elsevier Inc. All rights reserved.

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