• Michelle E Wilson, Mohammed Karaoui, Leyla Al Djasim, Deepak P Edward, Mohammad Al Shamrani, and David S Friedman.
• J Pediatr Ophthalmol Strabismus. 2014 May 1;51(3):154-9.

PurposeTo determine the safety and efficacy of high-dose oral chloral hydrate for pediatric ophthalmic procedures.MethodsThis study is a retrospective review of a quality audit of pediatric sedation for ophthalmic evaluation and imaging performed at King Khaled Eye Specialist Hospital between January 1 and December 31, 2011, in children aged 1 month to 6 years.ResultsThree hundred fifty-eight of 380 (94.2%) sedation procedures were successful after a single dose of chloral hydrate, with 356 of 380 (93.7%) children sedated within 45 minutes of the first dose. The total success rate of the sedation procedure increased to 97.9% (372 of 380) when a second dose was administered. Children adequately sedated after a single dose of chloral hydrate were on average younger and weighed less than children who required additional doses. No major adverse events were documented.ConclusionsThe use of chloral hydrate sedation for ophthalmic evaluation and imaging was safe and effective in this patient population with a high rate of procedure completion.Copyright 2014, SLACK Incorporated.

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