• P A Flecknell, I J Cruz, J H Liles, and G Whelan.
• Comparative Biology Centre, University of Newcastle upon Tyne, UK.
• Lab. Anim. 1996 Jan 1;30(1):67-74.

AbstractThe effects of induction of anaesthesia with halothane or isoflurane were studied in rabbits. The anaesthetic agents were delivered either via a face-mask, or the animals were placed in an anaesthetic induction chamber. All rabbits had periods of apnoea during induction, lasting 30-120 s, resulting in moderate hypercapnia and acidosis. Periods of apnoea were associated with a marked bradycardia. The combination of bradycardia and hypercapnia during induction may represent an increased risk of anaesthetic associated mortality. Animals in all groups tried to avoid inhaling anaesthetic vapour, and this behaviour, together with the occurrence of breath-holding suggests that induction was aversive.

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