• Thrombosis research · Aug 1999

    Review

    The use of prothrombin complex concentrates in the treatment of hemorrhages induced by oral anticoagulation.

    • G Pindur and S Mörsdorf.
    • Department of Clinical Haemostaseology and Transfusion Medicine, University of Saarland, Homburg/Saar, Germany. htgpin@med-rz.uni-sb.de
    • Thromb. Res. 1999 Aug 15;95(4 Suppl 1):S57-61.

    AbstractBleeding events are a common adverse effect in oral anticoagulation that frequently depend on the duration and intensity of treatment. Major bleeding events, particularly intracerebral hemorrhages, are a serious complication in cases that require the rapid reversal of anticoagulation. Urgent correction of the coagulation defect is also indicated when major emergency surgery is necessary. In addition to vitamin K supplementation, the administration of prothrombin complex concentrates is the most effective measure for the rapid reversal of anticoagulation. Due to the time-consuming administration and increased risk of volume overload, the administration of fresh frozen plasma is less advisable in such instances. The application of prothrombin complex concentrates requires a precautious risk-benefit evaluation, including an estimation of contraindications and repeated laboratory monitoring for dose adjustment.

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