• Patrick Goeres, Frederick A Zeiler, Bertram Unger, Dimitrios Karakitsos, and Lawrence M Gillman.
• Department of Surgery, University of Manitoba, Winnipeg, MB, Canada. Electronic address: goeresp@myumanitoba.ca.
• J Crit Care. 2016 Feb 1; 31 (1): 168-71.

BackgroundUltrasound assessment of optic nerve sheath diameter (ONSD) has been suggested as a non-invasive measure of intracranial pressure. Numerous small studies suggest its validity; however, discrepancy exists around normal values for ONSD. In this study we sought to define a normal value range for ONSD in a population of healthy adult volunteers.MethodsONSD was measured in healthy adult volunteers and a normal range was defined using descriptive statistics. A regression analysis was used to determine relationship between ONSD measurements and sex, age, height and weight.ResultsOne hundred twenty adults were recruited (age 18-65 [mean 29.3]) with 55 male and 65 female subjects. Mean ONSD was 3.68 mm (95% confidence interval [CI], 2.85-4.40). Upon regression analysis, mean ONSD did not vary with age, weight, or height but did vary with sex. Mean ONSD measurements for men were 3.78 mm (95% CI, 3.23-4.48) compared with 3.60 mm (95% CI, 2.83-4.11) for women.ConclusionThis study has defined the range of ONSD in a healthy cohort of volunteers. The lack of relationship to age, weight and height is similar to other studies but this is the first study to find a difference depending on sex suggesting the possible need for separate reference ranges for men and women.Copyright © 2015 Elsevier Inc. All rights reserved.

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