• Anasthesiol Intensivmed Notfallmed Schmerzther · Nov 2008

    [Inhaled nitric oxide for rescue treatment of refractory hypoxemia in ARDS patients].

    • Thilo Busch, Sven Bercker, Sven Laudi, Bernd Donaubauer, Bodil Petersen, and Udo Kaisers.
    • Department of Anesthesiology and Intensive Care Medicine, University of Leipzig, Leipzig, Germany. thilo.busch@medizin.uni-leipzig.de
    • Anasthesiol Intensivmed Notfallmed Schmerzther. 2008 Nov 1;43(11-12):778-83; quiz 784.

    AbstractThe acute respiratory distress syndrome (ARDS) is characterized by a maldistribution of pulmonary blood flow towards non-ventilated atelectatic lung areas being the main reason for intrapulmonary right-to-left shunt with the consequence of severe arterial hypoxemia. The application of inhaled nitric oxide (iNO) is a therapeutic option to selectively influence pulmonary blood flow in order to improve arterial oxygenation and to decrease pulmonary artery pressure without relevant systemic side effects. Although randomized controlled trials demonstrated no survival benefit in patient populations covering the entire severity range of acute lung injury, iNO represents a feasible rescue treatment for ARDS patients with severe refractory hypoxemia and is, therefore, an important option for ARDS therapy in specialized centers.

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