• Anesthesia and analgesia · Aug 1983

    Comparative Study

    Lidocaine and bupivacaine differential blockade of isolated canine nerves.

    • S K Palmer, Z J Bosnjak, F A Hopp, J H von Colditz, and J P Kampine.
    • Anesth. Analg. 1983 Aug 1;62(8):754-7.

    AbstractIn vitro studies of pharmacologic actions of local anesthetics are usually performed at room temperature using amphibian nerves exposed to local anesthetics for substantial periods of time. We performed in vitro studies of pharmacologic responses of motor A fibers and sensory C fibers to lidocaine and bupivacaine in clinically effective concentrations using a canine nerve preparation at body temperature with short exposure times to evaluate responses under clinically relevant conditions. Differential blockade of isolated, desheathed phrenic and vagus nerves was achieved with bupivacaine (0.58 mM), C fibers being blocked before A fibers (P less than 0.05). Lidocaine (2.8 mM) did not block A and C fibers differentially.

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